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AKBA is an active triterpenoid compound from the extract of Boswellia serrata and Boswellia carteri Birdw, exerts anti-inflammatory therapeutic effects and noncompetitively inhibits 5-lipoxygenase, topoisomerase, and leukocyte elastase. AKBA reduced the impact of proliferative retinopathies, protecting neurons against ischemic injury involving the Nrf2/HO-1 pathway. AKBA significantly inhibited human colon adenocarcinoma growth, showing arrest of the cell cycle in G1-phase and induction of apoptosis.
In vivo, AKBA significantly prevented the formation of intestinal adenomatous polyps without toxicity to mice. AKBA administration in mice effectively delayed the growth of HT-29 xenografts without signs of toxicity.
| Molecular Weight | 512.72 |
| Formula | C32H48O5 |
| CAS Number | 67416-61-9 |
| Solubility (25°C) | DMSO 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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