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AK-1

Cat. No. M8500

All AbMole products are for research use only, cannot be used for human consumption.

AK-1 Structure
Size Price Availability Quantity
10mM*1mL in DMSO USD 54 In stock
2mg USD 30 In stock
5mg USD 47 In stock
10mg USD 75 In stock
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Quality Control & Documentation
Biological Activity

AK-1 is a cell permeable, potent and specific SIRT2 inhibitor with an IC50 of 12.5 μM, it induced proteasomal degradation of the Snail transcription factor.

Chemical Information
Molecular Weight 403.45
Formula C19H21N3O5S
CAS Number 330461-64-8
Solubility (25°C) DMSO 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Anoop Kallingal, et al. Extraction and optimization of Penicillium sclerotiorum strain AK-1 pigment for fabric dyeing

[2] Zixiong Zhou, et al. AK-1, a Sirt2 inhibitor, alleviates carbon tetrachloride-induced hepatotoxicity in vivo and in vitro

[3] Chun-Yen Chen, et al. Cultivating Chlorella sorokiniana AK-1 with swine wastewater for simultaneous wastewater treatment and algal biomass production

[4] So Dam Lee, et al. AK-1, a SIRT2 inhibitor, destabilizes HIF-1α and diminishes its transcriptional activity during hypoxia

[5] F Gloria-Bottini, et al. Ak(1) genetic polymorphism and season of conception

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Keywords: AK-1 supplier, Sirtuin, inhibitors, activators

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