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Agnuside is a compound isolated from Vitex negundo with anti-arthritic activity. Agnuside down-regulates pro-inflammatory mediators PGE2 and LTB4, and reduces the expression of cytokines. Agnuside inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-glycoprotein (P-gp) ATPase activity at concentrations of 5, 25, and 100 μM, respectively. Agnuside (0.1-10 μM) induces proliferation of MCF-7 breast cancer cells, an effect that is inhibited by the estrogen receptor antagonist fulvestrant.
| Molecular Weight | 466.44 |
| Formula | C22H26O11 |
| CAS Number | 11027-63-7 |
| Form | Solid |
| Solubility (25°C) | DMSO |
| Storage | 2-8°C, protect from light, dry, sealed |
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