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Afoxolaner

Cat. No. M21814

All AbMole products are for research use only, cannot be used for human consumption.

Afoxolaner Structure
Size Price Availability Quantity
1mg USD 20 In stock
5mg USD 45 In stock
10mg USD 70 In stock
25mg USD 135 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod.

Chemical Information
Molecular Weight 625.87
Formula C26H17ClF9N3O3
CAS Number 1093861-60-9
Solubility (25°C) DMSO ≥ 120 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Marlene Drag, et al. J Vet Pharmacol Ther. Safety of oral afoxolaner formulated with or without milbemycin oxime in homozygous MDR1-deficient collie dogs

[2] Eric Tielemans, et al. Curr Res Parasitol Vector Borne Dis. Insecticidal efficacy of afoxolaner against Stomoxys calcitrans (Diptera: Muscidae) in dogs

[3] Rossella Panarese, et al. Vet Parasitol. Efficacy of afoxolaner for the treatment of ear mite infestation under field conditions

[4] Doug Carithers, et al. Parasit Vectors. Assessment of afoxolaner efficacy against Otodectes cynotis infestations of dogs

[5] Domenico Otranto. Vet Parasitol. NEXGARD®. Afoxolaner, a new oral insecticide-acaricide to control fleas and ticks in dogs. Editorial

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Keywords: Afoxolaner supplier, Parasite, inhibitors, activators

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