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Afabicin

Cat. No. M28562

All AbMole products are for research use only, cannot be used for human consumption.

Afabicin Structure
Synonym:

Debio 1450; AFN-1720

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Quality Control & Documentation
Biological Activity

Afabicin (Debio 1450) is the proagent of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci.

Chemical Information
Molecular Weight 485.43
Formula C23H24N3O7P
CAS Number 1518800-35-5
Form Solid
Solubility (25°C) Water 3.85 mg/mL (ultrasonic and warming and adjust pH to 10 with NaOH and heat to 60°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] J Nowakowska, et al. J Antimicrob Chemother. Evaluation of the microbiota-sparing properties of the anti-staphylococcal antibiotic afabicin

[2] Virginie Dyon-Tafani, et al. Int J Antimicrob Agents. Antimicrobial activity of the new FabI inhibitor afabicin desphosphono against intraosteoblastic Staphylococcus aureus

[3] Frédéric Peyrusson, et al. Int J Antimicrob Agents. Cellular pharmacokinetics and intracellular activity of the bacterial fatty acid synthesis inhibitor, afabicin desphosphono against different resistance phenotypes of Staphylococcus aureus in models of cultured phagocytic cells

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Keywords: Afabicin, Debio 1450; AFN-1720 supplier, Antibiotic, inhibitors, activators

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