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ADX71743

Cat. No. M8688

All AbMole products are for research use only, cannot be used for human consumption.

ADX71743 Structure

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Biological Activity

ADX71743 is a brain-penetrant, selective and potent negative allosteric modulator of metabotropic glutamate receptor 7 (mGlu7). In one study ADX71743 exhibited an anxiolytic-like profile in rat and mouse models without causing impairment of locomotor activity. In another study it induced absence epileptic seizures and lethargy.

Chemical Information
Molecular Weight 269.34
Formula C17H19NO2
CAS Number 1431641-29-0
Solubility (25°C) DMSO: 5 mg/mL (warmed)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Paulina Cieślik, et al. Negative Allosteric Modulators of mGlu 7 Receptor as Putative Antipsychotic Drugs

[2] Ida Marabese, et al. Metabotropic glutamate receptor subtype 7 in the dorsal striatum oppositely modulates pain in sham and neuropathic rats

[3] Valriane Tassin, et al. Phasic and Tonic mGlu7 Receptor Activity Modulates the Thalamocortical Network

[4] Rachel D Moloney, et al. Negative allosteric modulation of the mGlu7 receptor reduces visceral hypersensitivity in a stress-sensitive rat strain

[5] Mikhail Kalinichev, et al. ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization

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Keywords: ADX71743 supplier, inhibitors, activators

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