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Adjudin (also known as AF-2364) is a potent Cl- channel blocker, with a superior mitochondria-inhibitory effect. Adjudin inhibits cell proliferation in a dose dependent manner in SGC-7901 (human gastric adenocarcinoma cell), MDA-MB-231 (human breast adenocarcinoma cell), Smmc-7721 (human hepatoma cell) and MIA Paca-2 (human pancreatic adenocarcinoma cell) cells. The IC50 of Adjudin is determined to be 58.0 µM, 13.8 µM, 72.3 µM and 52.7 µM against SGC-7901, MDA-MB-231, Smmc-7721 and MIA Paca-2 cells, respectively, after treatment for 24 h. Similar results are obtained in other human and mice cancer cell lines. The IC50 of Adjudin in A549 cells and PC3 cells is 63.1 µM and 93.0 µM, respectively. Adjudin-treated mice show significant tumor growth inhibition compared with the control group (P<0.0001 in the human lung carcinoma cells A549 and P=0.006 in the prostate carcinoma cells PC3).
| Molecular Weight | 335.19 |
| Formula | C15H12Cl2N4O |
| CAS Number | 252025-52-8 |
| Solubility (25°C) | DMSO ≥ 16 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Chloride Channel Products |
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| Atractyloside potassium salt
Atractyloside potassium salt is a highly effective and specific inhibitor of mitochondrial ADP/ATP transport. Atractyloside potassium salt inhibited the chloride channel in rat heart mitochondrial membrane. Atractyloside potassium salt is a toxic diterpenoid glycoside, which can be isolated from the fruit of Atractyloside. |
| CaCCinh-A01
CaCCinh-A01 is a calcium-activated chloride channel (CaCC) inhibitor. |
| Eact
Eact is a activator of Ca 2+-activated Cl - channel transmembrane protein 16A (TMEM16A). |
| NPPB
NPPB is a blocker of the outwardly rectifying chloride channel (ORCC) with IC50 of 80 nM. NPPB has been shown to activate the GPR35-Gαi/o and GPR35-Gα16 pathways in HEK293 cells, inducing intracellular calcium mobilization. |
| T16Ainh-A01
T16Ainh-A01 is a Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A) inhibitor. |
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