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Ademetionine (S-adenosyl-l-methionine; SAMe) is a naturally-occurring substance which is a major source of methyl groups in the brain. Ademetionine (adenosylmethionine, S-adenosyl-L-methionine) is an orally active methyl donor utilised in studies of methylation processes involving DNA, RNA, proteins, and phospholipids. Ademetionine may also mitigate oxidative stress damage by regulating intracellular redox status. It finds application in research involving animal models of depression, alongside modulating neurotransmitter synthesis and metabolism.
| Cell Experiment | |
|---|---|
| Cell lines | NSCLC cell lines |
| Preparation method | 3 × 10^5 cells were seeded in 6-well plates and treated with 10% FBS fresh medium containing ademetionine 200 μM or DMSO as control. After 24 h, cells were collected, ready for theirsubsequent DNA and RNA extraction. |
| Concentrations | 200 μM |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 398.44 |
| Formula | C15H22N6O5S |
| CAS Number | 29908-03-0 |
| Solubility (25°C) | Water ≥ 40 mg/mL DMSO 80 mg/mL |
| Storage | 4°C, sealed |
| Related Metabolite/Endogenous Metabolite Products |
|---|
| 2'-Deoxyinosine
2′-Deoxyinosine is a nucleoside composed of hypoxanthine attached to 2′-deoxyribose via a β-N9-glycosidic bond. It is a DNA damage product resulting from the impairment of DNA by reactive nitrogen species. 2′-deoxyinsine can be used as a model compound to study the chemistry of adduct formation and radical chemistry that may affect DNA structures. 2′-Deoxyinosine is used to produce hybridization-sensitive fluorescent DNA probes with self-avoidance ability. |
| Ribitol
Ribitol (Adonitol) is a crystalline pentose alcohol formed by the reduction of ribose. |
| Glycodeoxycholic Acid
Glycodeoxycholic Acid is an endogenous metabolite. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis. |
| Glycolithocholic acid
Glycolithocholic acid, an endogenous metabolite, is a glycine conjugated secondary bile acid. Glycolithocholic acid can be used to study ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH0) and primary sclerosing cholangitis (PSC). |
| 4-Aminohippuric Acid
4-Aminohippuric acid is a typical substrate of organic anion transport systems. 4-Aminohippuric acid is a diagnostic agent, useful in medical tests involving the kidney, used in the measurement of renal plasma flow. |
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