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ADAMTS-5 Inhibitor is a potent ADAMTS-5 (aggrecanase-2) inhibitor, with an IC50 of 1.1 µM. ADAMTS-5 Inhibitor shows >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1).
| Molecular Weight | 449.92 |
| Formula | C16H11ClF3N3OS3 |
| CAS Number | 929634-33-3 |
| Form | Solid |
| Solubility (25°C) | DMSO 83.33 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Salvatore Santamaria. Int J Exp Pathol. ADAMTS-5: A difficult teenager turning 20
[3] Charles J Malemud. Biochem Pharmacol. Inhibition of MMPs and ADAM/ADAMTS
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