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ACT-389949 is a first-in-class, potent, selective formyl peptide receptor 2/lipoprotein A4 receptor (FPR2)/(ALX) agonist with an EC50 value of 3 nM for FPR2/ALX entry into monocytes.Additionally, ACT-389949 is an excellent tool compound for in vitro and in vivo to further analyze FPR2-regulated activity, which could be used in the development of next-generation FPR signaling-regulated anti-inflammatory therapies.
| Molecular Weight | 428.39 |
| Formula | C20H18F2N6O3 |
| CAS Number | 1258417-54-7 |
| Solubility (25°C) | DMSO 5 mg/mL (May need ultrasonic and adjust pH with HCl) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related FPR Products |
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| TC-FPR 43
TC-FPR 43 is a potent FPR2 agonist. |
| PBP10 TFA salt
PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects. |
| WKYMVM TFA
WKYMVM TFA is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist. |
| N-Formyl-Met-Leu-Phe
N-Formyl-Met-Leu-Phe (fMLP) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR), which can inhibit TNF-alpha secretion. |
| WRW4
WRW4 is a selective antagonist of formyl peptide receptor 1 (FPR1) signaling, it inhibits WKYMVm binding to FPR1 (IC50 = 0.23 μM). |
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