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Acolbifene

Cat. No. M45335

All AbMole products are for research use only, cannot be used for human consumption.

Acolbifene Structure
Synonym:

EM-652; SCH 57068

Price and Availability

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Quality Control & Documentation
Biological Activity

Acolbifene is an active metabolite of EM800 and an orally active pure anti-estrogen and selective estrogen receptor (ER) antagonist that inhibits estradiol-induced ERα (IC50 = 2 nM) and ERβ (IC50 = 0.4 nM) transcriptional activity and has anticancer activity.

Chemical Information
Molecular Weight 457.56
Formula C29H31NO4
CAS Number 182167-02-8
Form Solid
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Carol J Fabian, et al. Cancer Prev Res (Phila). Clinical Trial of Acolbifene in Premenopausal Women at High Risk for Breast Cancer

[2] Andrea R Genazzani, et al. Expert Opin Emerg Drugs. Emerging hormonal treatments for menopausal symptoms

[3] Mariam H Al-Dhaheri, et al. Steroids. Identification of novel proteins induced by estradiol, 4-hydroxytamoxifen and acolbifene in T47D breast cancer cells

[4] Sylvain Gauthier, et al. J Enzyme Inhib Med Chem. Synthesis and structure-activity relationships of analogs of EM-652 (acolbifene), a pure selective estrogen receptor modulator. Study of nitrogen substitution

[5] Ju Liu, et al. Chem Res Toxicol. Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methides

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Keywords: Acolbifene, EM-652; SCH 57068 supplier, Estrogen Receptor, inhibitors, activators

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