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Acenocoumarol is a warfarin analog, an anticoagulant that inhibits Vitamin K epoxide reductase. This results in depletion of the reduced form of vitamin K (vitamin KH2), limiting the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S, resulting in decreased prothrombin levels and the amount of thrombin generated.
BioRxiv. 2022 May 03;490380.
Multi-omics analyses of drug repurposing reveal Acebutolol and Amiloride for osteoporosis treatment
Acenocoumarol purchased from AbMole
| Molecular Weight | 353.33 |
| Formula | C19H15NO6 |
| CAS Number | 152-72-7 |
| Solubility (25°C) | DMSO heptane and xylene: ≥17 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Melisa Fragomeno, et al. Biomodification of acenocoumarol by bifidobacteria
[3] Abhijit Trailokya, et al. Acenocoumarol: A Review of Anticoagulant Efficacy and Safety
[4] Sergio Mondillo, et al. Rosuvastatin-acenocoumarol interaction
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