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Ac-FLTD-CMK is a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against caspases-1 (IC50 of 46.7 nM), caspases-4 (IC50 of 1.49 μM), caspases-5 (IC50 of 329 nM), and caspases-11 , but not the apoptotic caspases such as caspase-3.
| Molecular Weight | 569.05 |
| Formula | C26H37ClN4O8 |
| CAS Number | 2376255-48-8 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage | -20°C, protect from light, sealed |
[2] Brandon E Burdette, et al. Acta Pharm Sin B. Gasdermin D in pyroptosis
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