All AbMole products are for research use only, cannot be used for human consumption.
Ac-DEVD-CHO (10 μmol/L) partially blocks the effect of SIN-induced apoptosis and reduces the number of apoptotic nuclei. The addition of Ac-DEVD-CHO significantly prevents SLNT-induced apoptosis (from 32.91±1.21% decreases to 15.88±1.58% while NC and Ac-DEVD-CHO groups are 6.45±0.96%, 7.77±0.79%, respectively). The apoptosis rates of cells pretreated with Z-VAD-fmk (5.32%) or Ac-DEVD-CHO (7.43%) decrease obviously after hypericin-mediated PDT treatment.
| Molecular Weight | 502.47 |
| Formula | C20H30N4O11 |
| CAS Number | 169332-60-9 |
| Form | Solid |
| Solubility (25°C) | Water 1 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Caspase Products |
|---|
| PAC-1
PAC-1 is a procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC50 = 0.22 μM). |
| MDK83190
MDK83190 (Apoptosis Activator 2) strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells. |
| LY573636 (Tasisulam)
LY573636 is a novel anticancer agent that induces apoptosis through the intrinsic pathway and has antiangiogenic activity in preclinical models. |
| Q-VD-OPh
Q-VD-OPh is a potent, irreversible pan-caspase inhibitor with IC50 ranging from 25 to 400 nM for caspases 1, 3, 8, and 9, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis. |
| Z-DEVD-FMK
Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor with an IC50 of 18 μM, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
