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ABX464

Cat. No. M20710

All AbMole products are for research use only, cannot be used for human consumption.

ABX464 Structure
Synonym:

SPL-464; Obefazimod

Size Price Availability Quantity
5mg USD 60 In stock
10mg USD 90 In stock
25mg USD 196 In stock
50mg USD 315 In stock
100mg USD 440 In stock
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Quality Control & Documentation
Biological Activity

ABX464 is a reverse transcriptase (RT) inhibitor with anti-HIV activity that inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) from five different donors, with IC50 values between 0.1 μM and 0.5 μM, and can be used in studies related to ulcerative colitis.

Chemical Information
Molecular Weight 338.71
Formula C16H10ClF3N2O
CAS Number 1258453-75-6
Solubility (25°C) DMSO 68 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ccile Apolit, et al. Clin Transl Gastroenterol. ABX464 (obefazimod) up-regulates miR-124 to reduce pro-inflammatory markers in inflammatory bowel diseases

[2] Severine Vermeire, et al. Lancet Gastroenterol Hepatol. ABX464 (obefazimod) for moderate-to-severe, active ulcerative colitis: a phase 2b, double-blind, randomised, placebo-controlled induction trial and 48 week, open-label extension

[3] Sara Moron-Lopez, et al. Clin Infect Dis. ABX464 Decreases the Total Human Immunodeficiency Virus (HIV) Reservoir and HIV Transcription Initiation in CD4+ T Cells From Antiretroviral Therapy-Suppressed Individuals Living With HIV

[4] Jamal Tazi, et al. Drug Discov Today. Specific and selective induction of miR-124 in immune cells by the quinoline ABX464: a transformative therapy for inflammatory diseases

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Keywords: ABX464, SPL-464; Obefazimod supplier, Anti-infection, inhibitors, activators

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