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ABT-724 

Cat. No. M30511

All AbMole products are for research use only, cannot be used for human consumption.

ABT-724  Structure

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Quality Control & Documentation
Biological Activity

ABT-724 is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM). ABT-724 has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 could be useful for the treatment of erectile dysfunction and has favorable side-effect profile.

Chemical Information
Molecular Weight 293.37
Formula C17H19N5
CAS Number 70006-24-5
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Fabrizio Sanna, et al. Pharmacol Biochem Behav. Role of dopamine D4 receptors in copulatory behavior: Studies with selective D4 agonists and antagonists in male rats

[2] Ping Yin, et al. Neurosci Lett. ABT-724 alleviated hyperactivity and spatial learning impairment in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder

[3] Meena V Patel, et al. J Med Chem. Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction

[4] Marlon Cowart, et al. J Med Chem. Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction

[5] Jorge D Brioni, et al. Proc Natl Acad Sci U S A. Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats

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Keywords: ABT-724  supplier, Dopamine Receptor, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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