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ABL127

Cat. No. M8279

All AbMole products are for research use only, cannot be used for human consumption.

ABL127 Structure

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Biological Activity

ABL127 is a potent and selective inhibitor of Protein phosphatase methylesterase-1 (PME-1 or PPME-1). IC50 values were 11.1 nM and 6.4 nM in MDA-MB-231 and HEK 293T cells with no activity detected against >50 other serine hydrolases. PME-1 regulates the methylesterification state of protein phosphatase 2A (PP2A) and is implicated in cancer and neurodegeneration.

Chemical Information
Molecular Weight 332.35
Formula C17H20N2O5
CAS Number 1073529-41-5
Solubility (25°C) DMSO: ≥5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yilu Xu, et al. Regulation PP2Ac methylation ameliorating autophagy dysfunction caused by Mn is associated with mTORC1/ULK1 pathway

[2] Bin Wu, et al. Methionine-Mediated Protein Phosphatase 2A Catalytic Subunit (PP2Ac) Methylation Ameliorates the Tauopathy Induced by Manganese in Cell and Animal Models

[3] Sydney A Labuzan, et al. Inhibition of protein phosphatase methylesterase 1 dysregulates MAP kinase signaling and attenuates muscle cell differentiation

[4] Laiming Mo, et al. Inhibition of demethylation of protein phosphatase 2A catalytic subunit (PP2Ac) promotes M1 polarization of macrophages

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Keywords: ABL127 supplier, inhibitors, activators

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