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ABD957

Cat. No. M21136

All AbMole products are for research use only, cannot be used for human consumption.

ABD957 Structure

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Quality Control & Documentation
Biological Activity

ABD957 is a potent and selective covalent inhibitor of the ABHD17 family of depalmitoylases, inhibiting IC50 at an IC50 of 0.21 µM. ABD957 impaired N-Ras depalmitylation in AML cells, reducing N-Ras signaling and the growth of NRAS mutant AML cells.

Chemical Information
Molecular Weight 627.68
Formula C27H36F3N7O5S
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jarrett R Remsberg, et al. Nat Chem Biol. ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth

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Keywords: ABD957 supplier, MAGL, inhibitors, activators

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