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Calcimycin (A-23187), a calcium ionophore, is used to induce Ca(2+)-dependent cell death by increasing intracellular Ca(2+) concentration ([Ca(2+)](i)) under in vitro condition. Calcimycin (A-23187) promotes intracelllular ROS generation and platelet particle formation (fragmentation) in vitro and in vivo. Calcimycin (A-23187) induced trace Zn(2+), derived from cell preparation, partly attenuates the Ca(2+)-dependent cell death. Calcimycin (A-23187) can be used to induce autophagy in mammalian cells.
| Molecular Weight | 523.63 |
| Formula | C29H37N3O6 |
| CAS Number | 52665-69-7 |
| Solubility (25°C) | DMSO 27 mg/mL |
| Storage | 4°C, dry, sealed |
| Related CaMK Products |
|---|
| KN-62
KN-62 is a selective, cell permeable inhibitor of calcium/calmodulin-dependent kinase II (CaMKII; IC50 = 900 nM). |
| NH125
NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor. |
| KN-92
KN-92 is an inactive analog of the CaM kinase II inhibitor KN-93. |
| A 484954
A 484954 is a caM kinase III (eEF-2 kinase) inhibitor. |
| KN 93
KN 93 is a caM kinase II inhibitor; also K + channel blocker (K V). |
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