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Smurf1-IN-A01 is a high affinity Smurf1 E3 ubiquitin ligase inhibitor (Kd = 3.7 nM). Smurf1-IN-A01 attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling. Smurf1-IN-A01 potentiates BMP-2-induced osteoblastic activity in C2C12 myoblasts and MC3T3-E1 osteoblast precursor cells.
| Molecular Weight | 512.93 |
| Formula | C22H20ClF3N4O3S |
| CAS Number | 1007647-73-5 |
| Solubility (25°C) | DMSO 51.29 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Sai Shi, et al. Molecular mechanism of CaCC inh-A01 inhibiting TMEM16A channel
[4] No authors listed. J Cereb Blood Flow Metab. Poster Viewing Sessions PA00-A01 to PA00-A49
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