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A 987306

Cat. No. M6381

All AbMole products are for research use only, cannot be used for human consumption.

A 987306 Structure

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Quality Control & Documentation
Biological Activity

A 987306 is a potent histamine H4 receptor antagonist (pKi values are 8.24 and 8.47 in human and rat H4 receptors respectively). Displays 162-fold, 620-fold, and > 1600-fold selectivity over human H3, H1 and H2 receptors. Blocks zymosan-induced neutrophil reflux and attenuates thermal hypersensitivity in vivo (ED50 = 42 μmol/kg, ip).

Chemical Information
Molecular Weight 327.42
Formula C18H25N5O
CAS Number 1082954-71-9
Solubility (25°C) DMSO 32.74 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Dorota Lazewska, et al. Azines as histamine H4 receptor antagonists

[2] Huaqing Liu, et al. cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia

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