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A-967079 is a selective TRPA1 channel blocker (IC50 values are 67 and 289 nM at human and rat TRPA1 receptors respectively). A 967079 displays 1000-fold selectivity for TRPA1 over other TRP channels, and is >150-fold selective over 75 other ion channels, enzymes and G-protein-coupled receptors. A 967079 exhibits analgesic effects in a rat osteoarthritic pain model.
| Molecular Weight | 207.24 |
| Formula | C12H14FNO |
| CAS Number | 1170613-55-4 |
| Solubility (25°C) | DMSO 20.72 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Jianhua Zhao, et al. Irritant-evoked activation and calcium modulation of the TRPA1 receptor
[3] Stefan Heber, et al. A Human TRPA1-Specific Pain Model
[5] Ari Koivisto, et al. TRPA1: a transducer and amplifier of pain and inflammation
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| AMG-517
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| Phenazopyridine hydrochloride
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