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A-740003 is a potent and selective P2X7 receptor antagonist (IC50 values are 18 and 40 nM for rat and human receptors respectively). A-740003 displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100 μM. A-740003 reduces nociception in animal models of persistent neuropathic and inflammatory pain. A-740003 also reduces neuroblastoma tumor growth in mice.
| Molecular Weight | 474.55 |
| Formula | C26H30N6O3 |
| CAS Number | 861393-28-4 |
| Form | Solid |
| Solubility (25°C) | DMSO 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Jie Yin, et al. Role of P2X 7 R in the development and progression of pulmonary hypertension
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