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A 419259 trihydrochloride is a potent Hck inhibitor (IC50 = 0.43 nM). Also inhibits other Src family kinases (SFKs). Suppresses proliferation and induces apoptosis in CML cell lines including CD34+. Also inhibits acute myeloid leukemia (AML) stem cell proliferation in vitro and in vivo.
| Molecular Weight | 592.01 |
| Formula | C29H34N6O.3HCl |
| CAS Number | 1435934-25-0 |
| Form | Solid |
| Solubility (25°C) | Water 59.2 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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