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A 350619 hydrochloride is a activator of soluble guanylyl cyclase (sGC). Activates basal sGC and synergistically activates sGC in the presence of NO. Relaxes cavernosum smooth muscle in vitro and induces penile erections in rats. Induces a sustained increase in skin blood flow in vivo.
| Molecular Weight | 425.41 |
| Formula | C21H25ClN2OS.HCl |
| CAS Number | 1217201-17-6 |
| Solubility (25°C) | Water 42.54 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Guanylate Cyclase Products |
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Riociguat (BAY 63-2521) is an oral soluble guanylate cyclase (GC) stimulator, used in the research of ipulmonary hypertension. |
| BAY 41-2272
BAY 41-2272 is a soluble guanylyl cyclase (sGC) activator. |
| BAY 41-8543
BAY 41-8543 is a guanylyl cyclase (sGC) stimulator. |
| Linaclotide
Linaclotide is a potent and selective guanylate cyclase C agonist; developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation. |
| Ebselen Oxide
Ebselen oxide is a potent inhibitor of a-Methylacyl coenzyme A racemase (AMACR). |
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