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A-317491 sodium salt hydrate is a potent, selective and non-nucleotide antagonist of P2X3 and P2X2/3 receptors, with Kis of 22, 22, 9, and 92 nM for hP2X3, rP2X3, hP2X2/3, and rP2X2/3, respectively. A-317491 sodium salt hydrate is highly selective (IC50>10 μM) over other P2 receptors and other neurotransmitter receptors, ion channels, and enzymes. A-317491 sodium salt hydrate reduces inflammatory and neuropathic pain by blocking P2X3 and P2X2/3 receptor-mediated calcium flux.
| Molecular Weight | 606.57 |
| Formula | C33H29NNaO9 |
| CAS Number | 475205-49-3 (free base) |
| Solubility (25°C) | Water ≥ 90 mg/mL |
| Storage | 2-8°C, dry, sealed |
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