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A-286982 is a potent inhibitor of the LFA-1/ICAM-1 interaction, with IC50 values of 44 and 35 nM in LFA-1/ICAM-1 binding and LFA-1-mediated cell adhesion assays respectively. A-286982 binds to the I domain allosteric site (IDAS).
| Molecular Weight | 453.55 |
| Formula | C24H27N3O4S |
| CAS Number | 280749-17-9 |
| Form | Solid |
| Solubility (25°C) | DMSO 45.35 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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