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A-196 is a potent selective inhibitor of SUV420H1 and SUV420H2 with IC50 values of 25 nM and 144 nM, respectively, and biochemically inhibits SUV4-20 in a substrate-competitive manner. In addition, A-196 is a first-in-class chemical probe for SUV4-20, which can be used to study the role of histone methyltransferases in genome integrity.
| Molecular Weight | 359.25 |
| Formula | C18H16Cl2N4 |
| CAS Number | 1982372-88-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 7.18 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Xiao-Ying Zhang, et al. Scorpion venoms in gastric cancer
[4] Yang Cao, et al. miR-196 acts as a tumor suppressor in osteosarcoma by targeting HOXA9
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