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8-PIP-cAMP

Cat. No. M7999

All AbMole products are for research use only, cannot be used for human consumption.

8-PIP-cAMP Structure

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Biological Activity

Selective cAMP-dependent protein kinase (PKA) activator. Site selective cyclic AMP analog with high selectivity for site A of protein kinase A type I and for site B of type II. Acts synergistically together with analogs having opposite site-selectivity.

Chemical Information
Molecular Weight 434.32
Formula C15H20N6O6PNa
CAS Number 31357-06-9
Solubility (25°C) Water: freely soluble
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Elisa Stellaria Grassi, et al. 8-Cl-cAMP and PKA I-selective cAMP analogs effectively inhibit undifferentiated thyroid cancer cell growth

[2] Yara Rhayem, et al. Functional Characterization of PRKAR1A Mutations Reveals a Unique Molecular Mechanism Causing Acrodysostosis but Multiple Mechanisms Causing Carney Complex

[3] Alessandra Dicitore, et al. The cAMP analogs have potent anti-proliferative effects on medullary thyroid cancer cell lines

[4] Simona Lucchi, et al. 8-Chloro-cyclic AMP and protein kinase A I-selective cyclic AMP analogs inhibit cancer cell growth through different mechanisms

[5] C M Braun, et al. Co-regulation of antigen-specific T lymphocyte responses by type I and type II cyclic AMP-dependent protein kinases (cAK)

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Keywords: 8-PIP-cAMP supplier, inhibitors, activators

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