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8-Chloroadenosine

Cat. No. M6358

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8-Chloroadenosine Structure
Synonym:

8-Cl-Ado

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10mg USD 490 Custom Synthesis
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Biological Activity

8-Chloroadenosine is a nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226 and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells.

Chemical Information
Molecular Weight 301.69
Formula C10H12ClN5O4
CAS Number 34408-14-5
Solubility (25°C) DMSO 30.17 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jessica L Macer-Wright, et al. 8-Chloroadenosine Alters the Metabolic Profile and Downregulates Antioxidant and DNA Damage Repair Pathways in Macrophages

[2] Vickie Tang, et al. 8-Chloroadenosine induces apoptosis in human coronary artery endothelial cells through the activation of the unfolded protein response

[3] Alper Y Kearney, et al. 8-Chloroadenosine Sensitivity in Renal Cell Carcinoma Is Associated with AMPK Activation and mTOR Pathway Inhibition

[4] Jennifer B Dennison, et al. Intracellular succinylation of 8-chloroadenosine and its effect on fumarate levels

[5] C A Lange-Carter, et al. 8-Chloroadenosine mediates 8-chloro-cyclic AMP-induced down-regulation of cyclic AMP-dependent protein kinase in normal and neoplastic mouse lung epithelial cells by a cyclic AMP-independent mechanism

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Keywords: 8-Chloroadenosine, 8-Cl-Ado supplier, AMPK, inhibitors, activators

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