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7-Dehydrocholesterol (7-DHC) is a metabolic intermediate in cholesterol synthesis as well as an unsaturated sterol whose conjugated double bond on the sterol's B ring allows 7-DHC to take up free radicals, thereby counteracting the ability of free radicals to trigger lipid oxidation and iron death.
| Molecular Weight | 384.64 |
| Formula | C27H44O |
| CAS Number | 434-16-2 |
| Form | Solid |
| Solubility (25°C) | Ethanol 16.67 mg/mL DMSO 5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] Malgorzata JM Nowaczyk, et al. Smith-Lemli-Opitz Syndrome
| Related Ferroptosis Products |
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| Sulfasalazine
Sulfasalazine is a sulfonamide agent derived from Mesalazine. Sulfasalazine has xC-system inhibitory activity associated with iron death and is primarily used as an anti-inflammatory agent. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer. |
| Deferiprone
Deferiprone is the only orally active iron-chelating agent with an affinity for ferric ion (iron III)，binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values. |
| Erastin
Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. *The compound is unstable in solutions, freshly prepared is recommended |
| Ferrostatin-1
Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM. |
| Lithocholic acid
Lithocholic acid is a bile acid that acts as a detergent to solubilize fats for absorption, can also activate the vitamin D receptor. |
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