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6-Hydroxydopamine hydrochloride is an antagonist of the neurotransmitter dopamine.
*The compound is unstable in solutions, freshly prepared is recommended
Biomater Sci. 2022 Jun 14;10(12):3309-3322.
Dopamine-derived nanoparticles for the protection of irradiation-induced intestinal injury by maintaining intestinal homeostasis
6-Hydroxydopamine hydrochloride purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | MDA-MB-231 and MCF-7 cells |
| Preparation method | MDA-MB-231 or MCF-7 cells were treated with various concentrations of Liensinine and nuciferine in serum-free media for 24 h. |
| Concentrations | 0 - 60 μM |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | Institute of Cancer Research (ICR) mice |
| Formulation | The stored solutions of liensinine (1.0 mg/mL) and Midazolam (1.0 mg/mL) were prepared in methanol and water (1:1, v/v) |
| Dosages | 5 mg/kg |
| Administration | Oral administration |
| Molecular Weight | 205.64 |
| Formula | (HO)3C6H2CH2CH2NH2.HCl |
| CAS Number | 28094-15-7 |
| Solubility (25°C) | Water: ≥50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] H Cambridge, et al. Investigation of 6-hydroxydopamine-induced plasma extravasation in rat skin
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