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6,8-Diprenylnaringenin

Cat. No. M30477

All AbMole products are for research use only, cannot be used for human consumption.

6,8-Diprenylnaringenin Structure
Synonym:

Lonchocarpol A; Senegalensin

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Quality Control & Documentation
Biological Activity

6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and 3H-Methotrexate transport (IC50=0.41 μM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin.

Chemical Information
Molecular Weight 408.49
Formula C25H28O5
CAS Number 68236-11-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Tomasz Tronina, et al. Molecules. Flavonoids as Phytoestrogenic Components of Hops and Beer

[2] D B Clarke, et al. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. Determination of phytoestrogens in dietary supplements by LC-MS/MS

[3] N G Coldham, et al. Food Chem Toxicol. Identification, quantitation and biological activity of phytoestrogens in a dietary supplement for breast enhancement

[4] S R Milligan, et al. J Clin Endocrinol Metab. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids

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Keywords: 6,8-Diprenylnaringenin, Lonchocarpol A; Senegalensin supplier, BCRP/ABCG2/MXR/ABCP, inhibitors, activators

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