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Desmethylglycitein

Cat. No. M18181

All AbMole products are for research use only, cannot be used for human consumption.

Desmethylglycitein Structure
Synonym:

6,7,4'-Trihydroxyisoflavone

Size Price Availability Quantity
5mg USD 30 In stock
10mg USD 50 In stock
25mg USD 90 In stock
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Biological Activity

Desmethylglycitein (4',6,7-Trihydroxyisoflavone) is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1). Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes. Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity.

Chemical Information
Molecular Weight 270.24
Formula C15H10O5
CAS Number 17817-31-1
Form Solid
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yong-Hyun Ko, et al. Arch Pharm Res. Protective effects of 6,7,4'-trihydroxyisoflavone, a major metabolite of daidzein, on 6-hydroxydopamine-induced neuronal cell death in SH-SY5Y human neuroblastoma cells

[2] Yong-Hyun Ko, et al. Eur J Pharmacol. 6,7,4'-Trihydroxyisoflavone, a major metabolite of daidzein, improves learning and memory via the cholinergic system and the p-CREB/BDNF signaling pathway in mice

[3] Tae-Gyu Lim, et al. Cancer Prev Res (Phila). The Prolyl Isomerase Pin1 Is a Novel Target of 6,7,4'-Trihydroxyisoflavone for Suppressing Esophageal Cancer Growth

[4] Sang Gwon Seo, et al. Mol Nutr Food Res. A metabolite of daidzein, 6,7,4'-trihydroxyisoflavone, suppresses adipogenesis in 3T3-L1 preadipocytes via ATP-competitive inhibition of PI3K

[5] Dong Eun Lee, et al. Carcinogenesis. 6,7,4'-trihydroxyisoflavone inhibits HCT-116 human colon cancer cell proliferation by targeting CDK1 and CDK2

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Keywords: Desmethylglycitein, 6,7,4'-Trihydroxyisoflavone supplier, CDK, inhibitors, activators

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