Free shipping on all orders over $ 500

5HPP-33

Cat. No. M7843

All AbMole products are for research use only, cannot be used for human consumption.

5HPP-33 Structure

Price and Availability

For this product's availability, delivery time and price, please email inquiry@abmole.com directly or click the "Inquiry Now" button below.

Quality Control & Documentation
Biological Activity

5HPP-33 is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules. 5HPP-33 has shown inhibition of cell proliferation of both estrogen-dependent (MCF-7) and estrogen-independent (MDA-MB-231) breast cancer cells as well as other cell lines. A study in tubulin forming assay reported that 5HPP-33 acts as a microtubule formation inhibitor (IC50=810 nM).

Chemical Information
Molecular Weight 323.39
Formula C20H21NO3
CAS Number 105624-86-0
Solubility (25°C) DMSO: ≥20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Aijaz Rashid, et al. Thalidomide (5HPP-33) suppresses microtubule dynamics and depolymerizes the microtubule network by binding at the vinblastine binding site on tubulin

[2] Bulbul Pandit, et al. Structure-activity relationship studies of thalidomide analogs with a taxol-like mode of action

[3] Nicole Kleinstreuer, et al. A computational model predicting disruption of blood vessel development

[4] Masahiro Kizaki, et al. New tubulin polymerization inhibitor derived from thalidomide: implications for anti-myeloma therapy

[5] Toyotaka Iguchi, et al. Novel tubulin-polymerization inhibitor derived from thalidomide directly induces apoptosis in human multiple myeloma cells: possible anti-myeloma mechanism of thalidomide

Related Products
Lactate calcium

Lactate calcium is an excellent calcium fortifier that works better than inorganic calcium. Lactate calcium is used as an antacid.
Coniferyl ferulate

Coniferyl ferulate is a potent glutathione S-transferase (GST) inhibitor that reverses multidrug resistance and down-regulates p-glycoprotein. Coniferyl ferulate strongly inhibited human placental glutathione S-transferase with IC50 of 0.3 μM.
NXY-059

NXY-059 is a free radical-trapping neuroprotectant that has been reported to reduce infarct size and preserve brain function in experimental models of acute ischemic stroke.
Tie2 kinase inhibitor

Tie2 kinase inhibitor is a potent, reversible, and ATP-binding site-targeting Tie2 inhibitor with an IC50 of 250 nM.
Calcium levofolinate

Calcium levofolinate is a calcium salt of folinic acid that is an adjuvant used in cancer chemotherapy.
  Catalog
Abmole Inhibitor Catalog




Keywords: 5HPP-33 supplier, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.