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5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Sideritis tragoriganum, is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC50 of 0.35 μM.
| Molecular Weight | 388.37 |
| CAS Number | 2174-59-6 |
| Solubility (25°C) | DMSO 25 mg/mL |
| Storage | 2-8°C, protect from light |
| Related Lipoxygenase Products |
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