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5-Ethynyluridine

Cat. No. M30498

All AbMole products are for research use only, cannot be used for human consumption.

5-Ethynyluridine Structure
Synonym:

5-EU

Size Price Availability Quantity
5mg USD 50 In stock
10mg USD 85 In stock
25mg USD 155 In stock
50mg USD 260 In stock
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Quality Control & Documentation
Biological Activity

5-Ethynyluridine (5-EU) is a potent cell-permeable nucleoside can be used to label newly synthesized RNA. 5-Ethynyluridine can be used for isolation and sequencing of nascent RNA from neuronal populations in vivo. 5-Ethynyluridine can be used to identify changes in transcription in vivo in nervous system disease models.

Chemical Information
Molecular Weight 268.22
Formula C11H12N2O6
CAS Number 69075-42-9
Form Solid
Solubility (25°C) DMSO 10 mg/mL (ultrasonic and warming and heat to 60°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Sjors Maassen, et al. Chembiochem. 5-Ethynyluridine: A Bio-orthogonal Uridine Variant for mRNA-Based Therapies and Vaccines

[2] Lisanne J Van't Sant, et al. Acta Neuropathol Commun. In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration

[3] Xichen Bao, et al. Nat Methods. Capturing the interactome of newly transcribed RNA

[4] Radek Liboska, et al. PLoS One. Most anti-BrdU antibodies react with 2'-deoxy-5-ethynyluridine -- the method for the effective suppression of this cross-reactivity

[5] Dezhong Qu, et al. Anal Biochem. 5-Ethynylcytidine as a new agent for detecting RNA synthesis in live cells by "click" chemistry

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Keywords: 5-Ethynyluridine, 5-EU supplier, inhibitors, activators

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