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5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
| Cell Experiment | |
|---|---|
| Cell lines | A549 cells |
| Preparation method | Twenty-four hours after seeding, the cultures were treated with 20 µM EdUfor different time intervals, as described in the figure legends. In the pulse-chase experiments, the cells exposed to EdU were rinsed twice with medium, then suspended in the medium and cultured in the absence of EdU for time intervals as indicated in the figure legends. |
| Concentrations | 20 μM |
| Incubation time | 2, 4, or 6 h |
| Animal Experiment | |
|---|---|
| Animal models | C57BL/6 male mice |
| Formulation | Saline |
| Dosages | 123 mg/kg |
| Administration | Intraperitoneal injection |
| Molecular Weight | 252.22 |
| Formula | C11H12N2O5 |
| CAS Number | 61135-33-9 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage | 2-8°C, protect from light, dry, sealed |
| Related PROTAC Linker Products |
|---|
| 6-Maleimidocaproic Acid
A sulfhydryl reactive heterobifunctional crosslinking reagent. Widely used probe for introducing maleimides groups into biomolecules. A probe for thiol groups in proteins. |
| EGNHS
Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) is a homobifunctional, cleavable cross-linking reagent, it is mainly coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). |
| Ac4ManNAz
Ac4ManNAz is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
| L-Azidohomoalanine hydrochloride
L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. |
| DSPE-PEG-Biotin (MW 2000)
DSPE-PEG-Biotin (MW 2000) is a PROTAC linker, which belongs to the PEG class. It can be used to synthesize PROTAC molecules. |
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