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Domatinostat (4SC-202) induces a G2/M cell cycle arrest by interfering with the normal development of the mitotic spindle and causing collapsed spindle apparatus and multiple nucleation centres. In addition, Domatinostat (4SC-202) shows a broad anti-proliferative activity towards human cancer cell lines with a mean IC50 of 0.7 μM.
| Molecular Weight | 447.51 |
| Formula | C23H21N5O3S |
| CAS Number | 910462-43-0 |
| Solubility (25°C) | DMSO 80 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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