4-Phenylbutyric acid (4-PBA)

Biological Activity

4-Phenylbutyric acid is an inhibitor of HDAC, inhibits the growth of NSCLC Cell Lines at 2 mM. 4-Phenylbutyric acid is also an inhibitor of endoplasmic reticulum (ER) stress. 4-Phenylbutyric acid (0-5 mM) inhibits ASFV infection in a dose-dependent manner. LPS decreases the level of p62, whereas 4-Phenylbutyric acid reverses this decrease upon LPS stimulation for 48 h. The percentage of cells with LPS-induced AVOs is increased at 48 h, whereas 4-Phenylbutyric acid significantly reduces this percentage. Specifically, the percentage of cells with AVOs decreases from 61.6% to 53.1% upon 4-Phenylbutyric acid treatment, supporting that 4-Phenylbutyric acid inhibits LPS-induced autophagy.

Product Citations

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  Phytother Res. 2026 Jan 20; .

  Berberine Reduces Atrial Lipotoxicity and Endoplasmic Reticulum Stress to Alleviate Heart Failure With Preserved Ejection Fraction (HFpEF)‐Associated Atrial
  4-Phenylbutyric acid (4-PBA) purchased from AbMole

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  Journal of Environmental Sciences. 2025 Sep 26; .

  SeMet attenuates TBBPA-induced hepatocyte injury via inhibiting endoplasmic reticulum stress
  4-Phenylbutyric acid (4-PBA) purchased from AbMole

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  J Ethnopharmacol. 2025 Sep 26; .

  Salidroside improves hypoxia-induced milk synthesis disorder and endoplasmic reticulum stress via AKT/mTOR signaling in bovine mammary epithelial cells
  4-Phenylbutyric acid (4-PBA) purchased from AbMole

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  Veterinary Sciences. 2025 Dec 11; .

  NEFA Promotes Bovine Granulosa Cell Apoptosis via Activation of the PERK/eIF2α/ATF4/CHOP Pathway
  4-Phenylbutyric acid (4-PBA) purchased from AbMole

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  Pestic Biochem Physiol. 2024 Dec 28.

  An in-depth analysis of the effects of excessive acetochlor exposure on chicken liver health
  4-Phenylbutyric acid (4-PBA) purchased from AbMole

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  Small. 2023 Mar 12;e2208063.

  2D MoS2 Nanosheets Induce Ferroptosis by Promoting NCOA4-Dependent Ferritinophagy and Inhibiting Ferroportin
  4-Phenylbutyric acid (4-PBA) purchased from AbMole

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  New Phytol. 2023 Aug 22.

  Orosomucoid proteins limit endoplasmic reticulum stress in plants
  4-Phenylbutyric acid (4-PBA) purchased from AbMole

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  J Cell Physiol. 2023 Jan;238(1):151-164.

  Polystyrene nanoplastics aggravates lipopolysaccharide-induced apoptosis in mouse kidney cells by regulating IRE1/XBP1 endoplasmic reticulum stress pathway via oxidative stress
  4-Phenylbutyric acid (4-PBA) purchased from AbMole

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  Chemosphere. 2022 Nov;307(Pt 2):135962.

  Fine particulate matter induces heart defects via AHR/ROS-mediated endoplasmic reticulum stress
  4-Phenylbutyric acid (4-PBA) purchased from AbMole

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  Am J Pathol. 2021 Dec 5;192:468-483.

  The role of inactivated NF-κB in the occurrence of premature ovarian failure
  4-Phenylbutyric acid (4-PBA) purchased from AbMole

Chemical Information

Molecular Weight	164.2
Formula	C10H12O2
CAS Number	1821-12-1
Solubility (25°C)	DMSO ≥ 30 mg/mL Water 3 mg/mL at 40 ºC
Storage	2-8°C, dry, protect from light, sealed

References

[1] Hyun-Jung Park, et al. Biochem Pharmacol. 4-Phenylbutyric acid protects against lipopolysaccharide-induced bone loss by modulating autophagy in osteoclasts

[2] Goncalo Frouco, et al. Virus Res. Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14

[3] Shengmin Yan, et al. Free Radic Biol Med. Perfluorooctanoic acid exposure induces endoplasmic reticulum stress in the liver and its effects are ameliorated by 4-phenylbutyrate

[4] Tsg-Hui Chang, et al. Clin Cancer Res. Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung