All AbMole products are for research use only, cannot be used for human consumption.
4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is an orally active, selective estrogen receptor modulator (SERM). 4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) induces CRISPR/Cas9 systems based on ER mediated nucleus translocation.
| Cell Experiment | |
|---|---|
| Cell lines | MCF-7, MDA-MB-231, NCI-H460 |
| Preparation method | The authors also evaluate the effect, after 48 h, with a range of concentrations of compound 4 (0.39, 0.78, 1.56, 3.13, 6.25, and 12.50 μM), in presence and absence of 1.0 × 10^−1 μM of 4-OHT. Following this incubation period, cell growth was assessed by [3H]-thymidine incorporation and SRB assays. |
| Concentrations | 0.1 μM |
| Incubation time | 48 h |
| Animal Experiment | |
|---|---|
| Animal models | C57BL/6J and FVB/NJ mice |
| Formulation | Ethanol and corn oil |
| Dosages | 0.05 to 40 mg/kg |
| Administration | i.p. |
| Molecular Weight | 387.51 |
| Formula | C26H29NO2 |
| CAS Number | 68047-06-3 |
| Solubility (25°C) | Ethanol 20 mg/mL DMSO 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Estrogen Receptor Products |
|---|
| Fulvestrant
Fulvestrant is a Estrogen receptor (ER) antagonist with IC50 of 0.094 nM. Fulvestrant can also induce autophagy and apoptosis, and has anti-tumor effect. |
| LY500307
LY500307 is a potent, selective estrogen receptor beta agonist with an EC50 of 0.66 nM. |
| Calcitriol
Calcitriol is an Active metabolite of vitamin D3 that activates the vitamin D receptor. *The compound is unstable in solutions, freshly prepared is recommended |
| Tamoxifen Citrate (ICI 46474)
Tamoxifen Citrate is an antagonist of the estrogen receptor by competitive inhibition of estrogen binding. |
| 20-Hydroxyecdysone
20-Hydroxyecdysone (Ecdysterone, 20E) is a naturally occurring ecdysteroid hormone which controls the ecdysis (moulting) and metamorphosis of arthropods. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
