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4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria.
| Molecular Weight | 156.22 |
| CAS Number | 75899-68-2 |
| Form | Oily Liquid |
| Solubility (25°C) | DMSO 80 mg/mL |
| Storage | -20°C, sealed |
[1] Ariane Schrter, et al. 4-Hydroxynonenal is An Oxidative Degradation Product of Polysorbate 80
[4] Jos Pedro Castro, et al. 4-Hydroxynonenal (HNE) modified proteins in metabolic diseases
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