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5,7,4'-Trimethoxyflavone is a natural product isolated from the Thai plant Kaempferia parviflora (KP) and a CFTR activator with an EC50 of 64 μM. In addition, 5,7,4'-Trimethoxyflavone induces apoptosis, increases the activation of caspase-3 protein hydrolysis, and the degradation of poly (ADP-ribose) polymerase (PARP) protein.
| Molecular Weight | 312.32 |
| Formula | C18H16O5 |
| CAS Number | 5631-70-9 |
| Form | Solid |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Qin-Ge Ma, et al. Zhongguo Zhong Yao Za Zhi. [Studies on flavonoids from Cirsium setosum]
[2] Qi-Shi-San Wu, et al. Zhong Yao Cai. [Study on chemical constituents of Ixeris chinensis]
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| VX-770 (Ivacaftor)
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| Lonidamine
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| VX-809
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| CFTR(inh)-172
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