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3-Hydroxyanthranilic Acid (3-HAA, 3-HANA), a tryptophan metabolite, has an immunomodulatory effect that may result from inhibition of PI3K/Akt/mTOR and NF-κB activity, thereby decreasing the production of pro-inflammatory mediators.
Preparation of 3-hydroxyanthranilic acid solutions
The 3-HAA was dissolved in 1M NaOH and brought to a final concentration of 25mg/mL in phosphate buffered saline (PBS) after adjusting the pH to 7.2–7.4 with HCl.
Animals and animal treatments
Ldlr-/- mice (n=7–10 per group) received three intraperitoneal injectionsof PBS (200 uL) or 3-HAA (200 mg/kg in PBS, ~5 mg/injection) per week for 8 weeks and were sacrificed with CO2. Twelve-week-old mice were fed a high-fat diet [corn starch, cocoa butter, casein, glucose, sucrose, cellulose flour, minerals, and vitamins; 17.2% protein, 21% fat (62.9% saturated, 33.9% unsaturated, and 3.4% polyunsaturated), 0.15% cholesterol, 43% carbohydrates, 10% H2O, and 3.9% cellulose fibres] starting 2 days after the start of treatment.
https://pubmed.ncbi.nlm.nih.gov/22711758/
Redox Biol. 2025 Mar 11; .
The tryptophan metabolite 3-hydroxyanthranilic acid alleviates hyperoxia-induced bronchopulmonary dysplasia via inhibiting ferroptosis
3-Hydroxyanthranilic acid purchased from AbMole
| Molecular Weight | 153.14 |
| Formula | C7H7NO3 |
| CAS Number | 548-93-6 |
| Solubility (25°C) | DMSO 31 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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