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3-Bromocytisine

Cat. No. M6335

All AbMole products are for research use only, cannot be used for human consumption.

3-Bromocytisine Structure
Size Price Availability
10mg USD 440 Custom Synthesis
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Quality Control & Documentation
Biological Activity

3-Bromocytisine is a potent agonist of α4β4, α4β2 and α7 nACh receptors (IC50 values are 0.28, 0.30 and 31.6 nM respectively). Displays different effects on high (HS) and low (LS) ACh sensitivity α4β2 nAChRs (EC50 values are 0.008 and 0.05 μM respectively).

Chemical Information
Molecular Weight 269.14
Formula C11H13BrN2O
CAS Number 207390-14-5
Form Solid
Solubility (25°C) DMSO 26.91 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Shivani Choudhary, et al. Pharmacological characterization of a homomeric nicotinic acetylcholine receptor formed by Ancylostoma caninum ACR-16

[2] Juan Andrs Abin-Carriquiry, et al. Increase in locomotor activity after acute administration of the nicotinic receptor agonist 3-bromocytisine in rats

[3] J Andrs Abin-Carriquiry, et al. In vivo modulation of dopaminergic nigrostriatal pathways by cytisine derivatives: implications for Parkinson's Disease

[4] J Andrs Abin-Carriquiry, et al. C3-halogenation of cytisine generates potent and efficacious nicotinic receptor agonists

[5] L M Houlihan, et al. Activity of cytisine and its brominated isosteres on recombinant human alpha7, alpha4beta2 and alpha4beta4 nicotinic acetylcholine receptors

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Keywords: 3-Bromocytisine supplier, AChR/AChE, inhibitors, activators

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