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3α-Aminocholestane

Cat. No. M14481

All AbMole products are for research use only, cannot be used for human consumption.

3α-Aminocholestane Structure
Size Price Availability
5mg USD 110 1-2 Weeks
10mg USD 180 1-2 Weeks
25mg USD 360 1-2 Weeks
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Quality Control & Documentation
Biological Activity

3α-Aminocholestane is a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) inhibitor with an IC50 of ~2.5 μM.

Chemical Information
Molecular Weight 387.68
CAS Number 2206-20-4
Solubility (25°C) Ethanol 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Gwenny M Fuhler, et al. Therapeutic potential of SH2 domain-containing inositol-5'-phosphatase 1 (SHIP1) and SHIP2 inhibition in cancer

[2] Manoj Muthukuru, et al. TLR signaling that induces weak inflammatory response and SHIP1 enhances osteogenic functions

[3] Eui-Young So, et al. Inhibition of lipid phosphatase SHIP1 expands myeloid-derived suppressor cells and attenuates rheumatoid arthritis in mice

[4] Robert Brooks, et al. SHIP1 inhibition increases immunoregulatory capacity and triggers apoptosis of hematopoietic cancer cells

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  Catalog
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Keywords: 3α-Aminocholestane supplier, Phosphatase, inhibitors, activators

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