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2BAct is a highly selective, and orally active eIF2B (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct is able to penetrate the central nervous system (CNS). 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB.
| Molecular Weight | 440.8 |
| Formula | C19H16ClF3N4O3 |
| CAS Number | 2143542-28-1 |
| Form | Solid |
| Solubility (25°C) | DMSO 250 mg/mL (ultrasonic) |
| Storage | 4°C, protect from light |
| Related Eukaryotic Initiation Factor Products |
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| 4E1RCat
4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction, and inhibits the binding of eIF4G to eIF4E with IC50 of 3.2 μM. |
| 4EGI-1
4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 μM. |
| SBI-0640756
SBI-0640756 is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. |
| Zotatifin
Zotatifin is a first-in-class, sequentially selective inhibitor of RNA helicase eIF4A1. |
| GCN2iB
GCN2iB is an ATP-competitive inhibitor of a serine/threonine-protein kinase general control nonderepressible 2 (GCN2), with an IC50 of 2.4 nM. |
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Products are for research use only. Not for human use. We do not sell to patients.
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