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27-Hydroxycholesterol is a selective estrogen receptor modulator, and it is also an agonist of the liver X receptor. 27-Hydroxycholesterol significantly increases cell proliferation of LNCaP and PC3 cells and this effect can be attenuated by estrogen receptor inhibitors. 27-Hydroxycholesterol is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis. 27-Hydroxycholesterol also acts as an endogenous selective estrogen receptor modulator capable of increasing breast cancer growth and metastasis.
Exp Cell Res. 2024 Mar 8;437(1):113979.
High level 27-HC impairs trophoblast cell invasion and migration via LXR in pre-eclampsia
27-Hydroxycholesterol purchased from AbMole
| Molecular Weight | 402.65 |
| Formula | C27H46O2 |
| CAS Number | 20380-11-4 |
| Solubility (25°C) | Ethanol 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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