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22-Oxacalcitriol

Cat. No. M6325

All AbMole products are for research use only, cannot be used for human consumption.

22-Oxacalcitriol Structure
Synonym:

Maxacalcitol

Size Price Availability Quantity
10mg USD 680 In stock
25mg USD 1350 In stock
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Quality Control & Documentation
Biological Activity

Maxacalcitol (22-Oxacalcitriol) is a non-calcemic vitamin D3 analog and VDR ligand. Maxacalcitol (22-Oxacalcitriol) suppresses parathyroid hormone (PTH) mRNA expression in vitro and in vivo. Maxacalcitol (22-Oxacalcitriol) exhibits similar effects to calcitriol in osteoblast-like cells. Maxacalcitol (22-Oxacalcitriol) inhibits tumor growth of osteosarcoma in vitro in combination with all-trans retinoic acid.

Chemical Information
Molecular Weight 418.61
Formula C26H42O4
CAS Number 103909-75-7
Form Solid
Solubility (25°C) DMSO 42 mg/mL
Storage 4°C, protect from light, sealed
References

[1] Kazunori Inoue, et al. Maxacalcitol (22-Oxacalcitriol (OCT)) Retards Progression of Left Ventricular Hypertrophy with Renal Dysfunction Through Inhibition of Calcineurin-NFAT Activity

[2] Stephanie L Merrigan, et al. Calcitriol and non-calcemic vitamin D analogue, 22-oxacalcitriol, attenuate developmental and pathological choroidal vasculature angiogenesis ex vivo and in vivo

[3] C-N Zhou, et al. 22-oxacalcitriol protects myocardial ischemia-reperfusion injury by suppressing NF-κB/TNF-α pathway

[4] Magda Hamzawy, et al. 22-oxacalcitriol prevents acute kidney injury via inhibition of apoptosis and enhancement of autophagy

[5] Masahide Mizobuchi, et al. Clinical uses of 22-oxacalcitriol

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Keywords: 22-Oxacalcitriol, Maxacalcitol supplier, Vitamin, inhibitors, activators

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