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20-Hydroxyecdysone (ecdysterone or 20E) is a naturally occurring ecdysteroid hormone which controls the ecdysis (moulting) and metamorphosis of arthropods. 20-Hydroxyecdysone is also found most abundantly in plant species and has anabolic effects in vertebrates, i.e. increasing muscle size without androgen influence. 20-Hydroxyecdysone is produced from ecdysone (E) by the action of a P450 monooxygenase that hydroxylates E at carbon 20. When shade (shd, Drosophila P450 enzyme) is transfected into Drosophila S2 cells, extensive conversion of ecdysone (E) to 20-Hydroxyecdysone is observed. 20-Hydroxyecdysone regulates gene expression by binding to a nuclear receptor heterodimer, consisting of the ecdysone receptor (EcR) and ultraspiracle proteins (USP), which are orthologs of the vertebrate LXR and RXR receptors, respectively. Genes regulated by 20-Hydroxyecdysone, and dependent on EcR, account for many transcripts that are significantly up- or downregulated at puparium formation. 20-Hydroxyecdysone plays a key role in insect development, cell proliferaton, growth and apoptosis by controlling gene expression. 20-Hydroxyecdysone may protect PC12 cells against CoCl2-induced cell injury by inhibiting ROS production and modulating components of the mitochondrial apoptosis pathway. Many genes regulated by 20-Hydroxyecdysone in Kc167 cells are not regulated by 20-Hydroxyecdysone in salivary glands of wandering 3rd instar larvae, and 20-Hydroxyecdysone-induced levels of EcR isoforms EcR-RA, ER-RC, and EcR-RD/E differ between Kc cells and salivary glands suggesting a possible cause for the observed differences in 20-Hydroxyecdysone-regulated gene transcription between the two cell types. 20-Hydroxyecdysone is a potential fibrosis antagonist for renal proximal tubule cells through suppressing post-receptor signaling of TGF-β1 and restoring tubule epithelial character by blocking the expression of Snail.
BMC Biol. 2024 Mar 6;22(1):54.
A CTL − Lys immune function maintains insect metamorphosis by preventing gut bacterial dysbiosis and limiting opportunistic infections
20-Hydroxyecdysone purchased from AbMole
| Molecular Weight | 480.63 |
| Formula | C27H44O7 |
| CAS Number | 5289-74-7 |
| Solubility (25°C) | DMSO 76 mg/mL |
| Storage | -20°C, protect from light, sealed |
[2] Xiaoli Jin, et al. 20-Hydroxyecdysone-responsive microRNAs of insects
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